Cancers thrive primarily on glucose. Their metabolism is based on the so-called Warburg effect, which preferentially uses glycolysis over aerobic respiration. This is where two compounds come into play: 2-deoxyglucose (2-DG) and sodium dichloroacetate (DCA).
How does 2-DG work?
2-DG is a molecule very similar to glucose. Cancer cells “ingest” it but cannot process it further through glycolysis. This leads to energy starvation, cell growth arrest, and apoptosis.
What does DCA do?
DCA inhibits the PDK enzyme, which blocks pyruvate dehydrogenase. As a result, cells switch to aerobic respiration, which lowers their acidity and slows down their proliferation.
Synergy Potential
Research indicates that combining 2-DG and DCA can have a synergistic effect. One molecule deprives the cell of fuel, while the other forces it to change its driving force. Together, they can effectively weaken cancer cells without harming healthy tissue.
